Regulation of caspase expression and apoptosis by APC


Tingan Chen 1 , Ivana Yang 2 , Rosalyn Irby 1 , Kenneth H. Shain 1 , Hong-Gang Wang 3 , John Quackenbush 2,5 , Domenico Coppola 4 , Jin Q. Cheng 4 Timothy J. Yeatman 1§

Departments of Interdisciplinary Oncology and Surgery 1 , Drug Discovery 3 , Pathology 4 H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL; The Institute for Genomic Research 2 , Rockville, MD; The Department of Biochemistry, The George Washington University, Washington, DC

§ To whom queries should be addressed: yeatman@moffitt.usf.edu KEYWORDS: colon cancer; apoptosis; adenomatous polyposis coli (APC) gene; caspases; mouse models; microarray expression analysis

 
Affymetrix_data

APC(APC +/Min mouse) data
WildType data
Genes differentially expressed by 2 fold or more in APC(Min mouse) vs WT

cDNA_data directory

Min vs WT_1
Min vs WT_2
Min vs WT_3
Genes differentially expressed by greater than 2SD using slice analysis in MIDAS.

Intersection of the two Datasets

Affy_2fold vs cDNA_2SD_intersection